Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | PTGFR | P43088 | 4/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373064 | 0.91 | PTGFR (0.40) | TRPV4PTGFRTACR2TACR3KCNH2 | |
| SCHEMBL2372311 | 0.89 | TRPV4 (0.40) | TRPV4CTSADHODHPTGFRTACR2 | |
| SCHEMBL2373084 | 0.89 | DHODH (0.49) | CTSADHODHPTGFRCYP1A2CYP2C19 | |
| SCHEMBL2465453 | 0.88 | TRPV4 (0.38) | TRPV4PTGFRTACR2TACR3KCNH2 | |
| SCHEMBL2373306 | 0.83 | DHODH (0.51) | TRPV4DHODHPTGFRCYP1A2CYP2C19 | |
| SCHEMBL2372142 | 0.83 | CTSA (0.44) | TRPV4CTSAPTGFRMEN1ALDH1A1 | |
| SCHEMBL2372484 | 0.82 | CTSA (0.38) | TRPV4CTSAPTGFRTACR2TACR3 | |
| SCHEMBL2372559 | 0.81 | TRPV4 (0.50) | TRPV4DHODHPTGFRTACR2TACR3 | |
| SCHEMBL2373699 | 0.81 | CTSA (0.44) | TRPV4CTSAPTGFRMEN1ALDH1A1 | |
| SCHEMBL2372846 | 0.81 | CTSA (0.41) | TRPV4CTSAPTGFRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |