Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372472 | 0.92 | PLA2G2A (0.51) | LMNAKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2372251 | 0.89 | TRPV4 (0.51) | MAPTPLA2G2ATRPV4TACR3 | |
| SCHEMBL2372559 | 0.88 | TRPV4 (0.50) | KDM4ESMN1; SMN2DHODHTRPV4TACR2 | |
| SCHEMBL2373092 | 0.87 | KDM4E (0.56) | LMNAKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2373306 | 0.86 | DHODH (0.51) | KDM4ECYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL2372142 | 0.86 | CTSA (0.44) | LMNATP53MAPTTRPV4 | |
| SCHEMBL2372047 | 0.86 | PTGS2 (0.43) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2373699 | 0.86 | CTSA (0.44) | LMNATP53MAPTTRPV4 | |
| SCHEMBL2373287 | 0.86 | TRPV4 (0.52) | LMNAKDM4ETP53MAPTTRPV4 | |
| SCHEMBL2372854 | 0.85 | MAPT (0.43) | LMNAKDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |