Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | PLAT | P00750 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373029 | 0.92 | DHODH (0.57) | DHODHPLAUPLATPLGPTGFR | |
| SCHEMBL2373290 | 0.91 | DHODH (0.59) | DHODHTRPV4GSK3AGSK3BPLAU | |
| SCHEMBL2373263 | 0.90 | TRPV4 (0.49) | DHODHTRPV4GSK3AGSK3BKDM4E | |
| SCHEMBL2374017 | 0.89 | DHODH (0.45) | DHODHTRPV4GSK3AGSK3BKDM4E | |
| SCHEMBL2371969 | 0.88 | DHODH (0.44) | DHODHTRPV4GSK3AGSK3BKDM4E | |
| SCHEMBL2372769 | 0.88 | PTGFR (0.54) | DHODHTRPV4KDM4EPTGFR | |
| SCHEMBL2373092 | 0.88 | KDM4E (0.56) | DHODHKDM4EGAAPTGFRMAPT | |
| SCHEMBL2373011 | 0.87 | DHODH (0.58) | DHODHTRPV4KDM4EGAAPTGFR | |
| SCHEMBL2372251 | 0.87 | TRPV4 (0.51) | TRPV4GSK3AGSK3BPLAUPLAT | |
| SCHEMBL2372696 | 0.86 | DHODH (0.48) | DHODHKDM4EGAAPTGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |