Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372595 | 0.88 | SMN1; SMN2 (0.54) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4668037 | 0.87 | TACR3 (0.53) | PLA2G2AMEN1KMT2ASMN1; SMN2TACR3 | |
| SCHEMBL2373101 | 0.85 | MAPT (0.69) | KDM4EMAPTPLA2G2AMEN1KMT2A | |
| SCHEMBL2372559 | 0.84 | TRPV4 (0.50) | KDM4ESMN1; SMN2TRPV4TACR3DHODH | |
| SCHEMBL2373216 | 0.81 | LMNA (0.51) | KDM4EMAPTPLA2G2ASMN1; SMN2TRPV4 | |
| SCHEMBL2372472 | 0.81 | PLA2G2A (0.51) | KDM4EMAPTPLA2G2AMEN1KMT2A | |
| SCHEMBL27729454 | 0.79 | LMNA (0.53) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4875432 | 0.79 | KDM4E (0.49) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4868977 | 0.76 | MEN1 (0.54) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14115125 | 0.76 | SMN1; SMN2 (0.54) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |