Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 8/20 | 0.32 |
| ▸ | LDHB | P07195 | 4/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21340222 | 1.00 | LMNA (0.35) | LMNATSHRTAS1R3TAS1R1HAO1 | |
| SCHEMBL19904656 | 0.76 | TAS1R3 (0.35) | TAS1R3TAS1R1LDHALDHBTAS1R2 | |
| SCHEMBL19904654 | 0.76 | CA1 (0.34) | TSHRKDM4EL3MBTL1 | |
| SCHEMBL1139693 | 0.73 | DPP4 (0.39) | LMNATSHRHAO1LDHALDHB | |
| SCHEMBL2657669 | 0.72 | LMNA (0.39) | LMNATSHRHAO1LDHALDHB | |
| SCHEMBL9264331 | 0.71 | RAB9A (0.46) | TSHRTAS1R3TAS1R1LDHALDHB | |
| SCHEMBL9264328 | 0.71 | RAB9A (0.46) | TSHRTAS1R3TAS1R1LDHALDHB | |
| SCHEMBL9264336 | 0.71 | RAB9A (0.46) | TSHRTAS1R3TAS1R1LDHALDHB | |
| SCHEMBL1856547 | 0.69 | CA12 (0.37) | LMNATSHRTAS1R3TAS1R1HAO1 | |
| SCHEMBL5636187 | 0.68 | SLC6A2 (0.41) | LMNATSHRTP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912977-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| EP-3046920-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARM INC (US) | 2021-08-04 | — | — | EP | disclosed |