Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR2 | P14207 | 1/20 | 0.54 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.54 |
| ▸ | GART | P22102 | 1/20 | 0.54 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.54 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.54 |
| ▸ | FPR2 | P25090 | 3/20 | 0.50 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.49 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551660 | 0.89 | FOLR2 (0.55) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005217 | 0.82 | FPR2 (0.57) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005214 | 0.82 | FPR2 (0.57) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005175 | 0.76 | FPR2 (0.63) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005176 | 0.76 | FPR2 (0.63) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005246 | 0.76 | FPR2 (0.56) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005243 | 0.76 | FPR2 (0.56) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL18540790 | 0.73 | GART (0.91) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005200 | 0.72 | FPR2 (0.56) | FOLR2FOLR1GARTSLC19A1SLC46A1 | |
| SCHEMBL23005199 | 0.72 | FPR2 (0.56) | FOLR2FOLR1GARTSLC19A1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | FOLR2 83/4885FOLR1 54/4885GART 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.