Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681285 | 0.85 | SMN1; SMN2 (0.51) | ATRMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL23732523 | 0.82 | RAB9A (0.48) | ATRTP53MAPTKDM4EALDH1A1 | |
| SCHEMBL12198422 | 0.81 | ATR (0.48) | ATRNOS1ACVR2ATGFBR2MEN1 | |
| SCHEMBL23732810 | 0.81 | KCNH2 (0.46) | ATRALOX5APFEN1LTA4H | |
| SCHEMBL15308507 | 0.80 | KCNH2 (0.60) | ATR | |
| SCHEMBL15308477 | 0.79 | MAP4K4 (0.49) | ATRTP53MAPTCYP1A2MCL1 | |
| SCHEMBL23732813 | 0.78 | ATR (0.48) | ATRNOS1ACVR2ATGFBR2KDM4E | |
| SCHEMBL12198431 | 0.78 | ATR (0.56) | ATRMEN1KMT2AKDM4EPOLB | |
| SCHEMBL20848406 | 0.77 | ATR (0.44) | ATRALOX5APFEN1 | |
| SCHEMBL18895999 | 0.76 | ATR (0.64) | ATRACVR2ATGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155004-A1 | STRAD-BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-05 | — | — | WO | disclosed |