Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375825 | 0.87 | TSHR (0.50) | TSHRTDP1MAPTPOLBNPY5R | |
| SCHEMBL10591724 | 0.84 | ALDH1A1 (0.43) | GAATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL13538573 | 0.83 | GAA (0.40) | GAATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL17758874 | 0.83 | NPY5R (0.45) | GAAALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL5953798 | 0.83 | MEN1 (0.42) | GAATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL9097023 | 0.83 | NPY5R (0.47) | ALDH1A1CYP3A4MAPK1TDP1MEN1 | |
| SCHEMBL19331880 | 0.82 | NPY5R (0.39) | GAATSHRMAPK1MEN1KMT2A | |
| SCHEMBL2493713 | 0.81 | TSHR (0.44) | TSHRMAPTPOLBNPY5RHDAC1 | |
| SCHEMBL16062693 | 0.81 | POLB (0.46) | TSHRALDH1A1TDP1MAPTPOLB | |
| SCHEMBL23822678 | 0.79 | TSHR (0.43) | TSHRMAPTPOLBNPY5RHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363392-B1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2017-05-03 | — | — | EP | disclosed |
| US-8840866-B2 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-09-23 | — | — | US | disclosed |
| US-8840866-B2 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-09-23 | — | — | US | disclosed |
| CN-101522624-B | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | UNIV PENNSYLVANIA | 2013-11-06 | — | — | CN | disclosed |
| US-8506929-B2 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-08-13 | — | — | US | disclosed |
| US-8506929-B2 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-08-13 | — | — | US | disclosed |
| US-20130129624-A1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130129624-A1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-05-23 | — | — | US | disclosed |
| EP-1999109-B1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2011141515-A1 | DIAGNOSTIC AGENTS FOR AMYLOID BETA IMAGING | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |
| US-7687052-B2 | radiolabeling; neurodegenerative diseases | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| CN-101522624-A | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | UNIV PENNSYLVANIA (US) | 2009-09-02 | — | — | CN | disclosed |
| US-20090123369-A1 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090123369-A1 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-05-14 | — | — | US | disclosed |
| EP-1999109-A2 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees Of The University Of Pennsylvania (US) | 2008-12-10 | — | — | EP | disclosed |
| US-20080038195-A1 | radiolabeling; neurodegenerative diseases | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-02-14 | — | — | US | disclosed |
| US-20080038195-A1 | radiolabeling; neurodegenerative diseases | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-02-14 | — | — | US | disclosed |
| WO-2007126733-A2 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130129624-A1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | APP, APBA1, PSEN1 | GAA 2031/4885TSHR 3343/4885ALDH1A1 3305/4885 |
| US-20080038195-A1 | radiolabeling; neurodegenerative diseases | APP, PSEN1, HTT | GAA 222/4885TSHR 3178/4885ALDH1A1 2974/4885 |
| US-20090123369-A1 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques | APP, APBA1, PSEN1 | GAA 2031/4885TSHR 3343/4885ALDH1A1 3305/4885 |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | GAA 31/4885TSHR 4782/4885ALDH1A1 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.