Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372797 | 0.93 | DHODH (0.66) | DHODHTSHRPDE10APTGFR | |
| SCHEMBL2372822 | 0.91 | DHODH (0.49) | DHODHTRPV4GSK3AGSK3BPLG | |
| SCHEMBL2372758 | 0.89 | DHODH (0.56) | DHODHTSHRPDE10ATRPV4PTGFR | |
| SCHEMBL2373047 | 0.87 | DHODH (0.54) | DHODHTSHRPDE10ATRPV4PTGFR | |
| SCHEMBL2372605 | 0.86 | DHODH (0.53) | DHODHTSHRPDE10ATRPV4PTGFR | |
| SCHEMBL2372855 | 0.86 | DHODH (0.71) | DHODHTSHRPDE10APTGFR | |
| SCHEMBL5945399 | 0.85 | PDE10A (0.68) | DHODHTSHRPDE10A | |
| SCHEMBL2373037 | 0.85 | DHODH (0.70) | DHODHTSHRPDE10ASMN1; SMN2 | |
| SCHEMBL2371929 | 0.85 | DHODH (0.61) | DHODHTSHRPDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL2373029 | 0.84 | DHODH (0.57) | DHODHPLGPLAUPLATPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |