Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 4/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372758 | 0.92 | DHODH (0.56) | DHODHPDE10ATSHRTRPV4NR1I2 | |
| SCHEMBL2374017 | 0.91 | DHODH (0.45) | DHODHTRPV4NR1I2PTGFRESR1 | |
| SCHEMBL2372605 | 0.88 | DHODH (0.53) | DHODHPDE10ATSHRTRPV4NR1I2 | |
| SCHEMBL2373290 | 0.87 | DHODH (0.59) | DHODHPDE10ATSHRTRPV4PTGFR | |
| SCHEMBL2372552 | 0.85 | DHODH (0.62) | DHODHPDE10ATSHRPTGFR | |
| SCHEMBL2373263 | 0.83 | TRPV4 (0.49) | DHODHTRPV4NR1I2PTGFR | |
| SCHEMBL2373069 | 0.82 | TRPV4 (0.46) | TRPV4NR1I2ESR1ESR2 | |
| SCHEMBL2372855 | 0.81 | DHODH (0.71) | DHODHPDE10ATSHRPTGFR | |
| SCHEMBL2371929 | 0.81 | DHODH (0.61) | DHODHPDE10ATSHRPTGFR | |
| SCHEMBL2373037 | 0.81 | DHODH (0.70) | DHODHPDE10ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |