Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373044 | 0.90 | ADK (0.43) | ADKGPR119JAK2JAK1PIK3CD | |
| SCHEMBL2373910 | 0.88 | SRC (0.45) | ADKSRCEGFRHCKFLT3 | |
| SCHEMBL2375243 | 0.83 | GPR119 (0.39) | ADKGPR119JAK2JAK1PIK3CD | |
| SCHEMBL357171 | 0.83 | SRC (0.52) | ADKGPR119PIK3CDSRCEGFR | |
| SCHEMBL28800796 | 0.81 | ADK (0.47) | ADKJAK2JAK1SRCEGFR | |
| SCHEMBL2373942 | 0.78 | ADK (0.44) | ADKSRCEGFRHCKFLT3 | |
| SCHEMBL25612068 | 0.76 | ADK (0.51) | ADKSRCEGFRHCKFLT3 | |
| SCHEMBL18640950 | 0.75 | ADK (0.54) | ADKSRCEGFRFLT3 | |
| SCHEMBL355610 | 0.75 | GPR119 (0.42) | GPR119 | |
| SCHEMBL1942725 | 0.73 | ADK (0.52) | ADKJAK2SRCEGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |