Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374068 | 0.89 | BTK (0.46) | GPR119BTKJAK2JAK1HSP90AA1 | |
| SCHEMBL869298 | 0.86 | FAAH (0.42) | GPR119BTKPIK3CDFAAH | |
| SCHEMBL27889184 | 0.83 | BTK (0.42) | BTKJAK2JAK1ADKHSP90AA1 | |
| SCHEMBL2373341 | 0.83 | ADK (0.42) | GPR119PIK3CDJAK2JAK1KIT | |
| SCHEMBL2373044 | 0.77 | ADK (0.43) | GPR119PIK3CDJAK2JAK1KIT | |
| SCHEMBL869772 | 0.75 | SRC (0.49) | GPR119BTKFAAHHSP90AA1HSP90AB1 | |
| SCHEMBL2373910 | 0.72 | SRC (0.45) | ADK | |
| SCHEMBL27889143 | 0.72 | BTK (0.52) | BTKJAK2JAK1HSP90AA1HSP90AB1 | |
| SCHEMBL868204 | 0.71 | ADK (0.41) | PIK3CDADK | |
| SCHEMBL4014703 | 0.69 | MAPT (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |