Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | POLA1 | P09884 | 1/20 | 0.63 |
| ▸ | POLD1 | P28340 | 1/20 | 0.63 |
| ▸ | TK1 | P04183 | 5/20 | 0.55 |
| ▸ | DTYMK | P23919 | 4/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23734160 | 1.00 | POLB (0.63) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL19663297 | 1.00 | POLB (0.63) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL24913490 | 0.94 | POLB (0.62) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL21786791 | 0.94 | POLB (0.61) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL19662171 | 0.92 | POLB (0.60) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL24023167 | 0.91 | POLB (0.66) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL23434907 | 0.91 | POLB (0.66) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL18840574 | 0.91 | POLB (0.66) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL18844519 | 0.90 | POLB (0.65) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL23734387 | 0.90 | POLB (0.67) | POLBPOLA1POLD1TK1DTYMK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411860-A1 | DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-12-29 | — | — | US | disclosed |
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411860-A1 | DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | POLL, POLQ, POLB | POLB 3/4885POLA1 11/4885POLD1 46/4885 |
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | POLRMT, RNGTT, MTR | POLB 10/4885POLA1 71/4885POLD1 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.