Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | EIF2AK3 | Q9NZJ5 | 8/20 | 0.44 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869352 | 0.76 | EIF2AK3 (0.75) | MEN1KMT2AEIF2AK3EIF2AK1LCK | |
| SCHEMBL13860400 | 0.74 | KMT2A (0.60) | MEN1KMT2ACYP11B2CYP11B1EIF2AK3 | |
| SCHEMBL2374826 | 0.71 | EIF2AK3 (0.56) | CYP11B2CYP11B1EIF2AK3EIF2AK1LCK | |
| SCHEMBL868654 | 0.70 | EIF2AK3 (0.76) | EIF2AK3 | |
| SCHEMBL869583 | 0.70 | EIF2AK3 (0.81) | EIF2AK3EIF2AK1LCKAURKB | |
| SCHEMBL2374124 | 0.69 | EIF2AK3 (0.69) | CYP11B2CYP11B1EIF2AK3EIF2AK1LCK | |
| SCHEMBL2075388 | 0.66 | SCN3A (0.65) | MEN1KMT2ALMNAGAA | |
| SCHEMBL4527947 | 0.64 | CYP11B1 (0.78) | CYP11B2CYP11B1EIF2AK3EIF2AK1LCK | |
| SCHEMBL869382 | 0.64 | EIF2AK3 (0.76) | CYP11B2CYP11B1EIF2AK3EIF2AK1LCK | |
| SCHEMBL2374711 | 0.64 | EIF2AK3 (0.71) | CYP11B2CYP11B1EIF2AK3SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |