Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 11/20 | 0.56 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374124 | 0.88 | EIF2AK3 (0.69) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL2374303 | 0.85 | EIF2AK3 (0.60) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL869729 | 0.84 | EIF2AK3 (0.80) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL13860439 | 0.80 | EIF2AK3 (0.55) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL869382 | 0.75 | EIF2AK3 (0.76) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL869352 | 0.73 | EIF2AK3 (0.75) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL30301904 | 0.72 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL868900 | 0.72 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 | |
| SCHEMBL867757 | 0.72 | EIF2AK3 (0.78) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL2373424 | 0.71 | MEN1 (0.50) | EIF2AK3EIF2AK1LCKAURKBCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |