Sugi Predict

Sugi Predict / Compounds / SCHEMBL23734296

SCHEMBL23734296

SCHEMBL23734296

CC(C)(CN)SSCOCC#Cc1cn([C@H]2CC(OCN=[N+]=[N-])[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)nc1N

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLG P54098 2/20 0.38
▸ POLB P06746 1/20 0.37
▸ POLA1 P09884 1/20 0.37
▸ POLD1 P28340 1/20 0.37
▸ P2RY2 P41231 7/20 0.33
▸ P2RY4 P51582 3/20 0.33
▸ P2RY6 Q15077 5/20 0.33
▸ GPR17 Q13304 2/20 0.32
▸ ENPP1 P22413 1/20 0.32
▸ P2RY1 P47900 1/20 0.32
▸ P2RX1 P51575 1/20 0.32
▸ P2RX3 P56373 1/20 0.32
▸ P2RY11 Q96G91 1/20 0.32
▸ P2RX4 Q99571 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23734227 0.92 POLG (0.40) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL23734360 0.91 POLG (0.41) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL24825153 0.91 POLG (0.41) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL23734288 0.91 POLG (0.40) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL23734503 0.90 POLG (0.39) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL23734524 0.89 POLB (0.35) POLBPOLA1POLD1P2RX1P2RX3
SCHEMBL23734304 0.89 POLB (0.48) POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL23734243 0.88 POLB (0.39) POLBPOLA1POLD1P2RY2P2RY4
SCHEMBL24905783 0.85 POLG (0.41) POLGPOLBPOLA1POLD1P2RY2
SCHEMBL23734146 0.85 POLG (0.41) POLGPOLBPOLA1POLD1P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230160000-A1 SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-05-25 — — US disclosed
US-20230160000-A1 SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-05-25 — — US disclosed
US-20230028388-A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-01-26 — — US disclosed
US-20220411860-A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-12-29 — — US disclosed
US-11085076-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-08-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220411860-A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS POLL, POLQ, POLB POLG 31/4885POLB 3/4885POLA1 11/4885
US-20230028388-A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS RNGTT, POLRMT, MTR POLG 315/4885POLB 18/4885POLA1 70/4885
US-11085076-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis POLRMT, RNGTT, MTR POLG 267/4885POLB 10/4885POLA1 71/4885
US-20230160000-A1 SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS POLRMT, RNGTT, MTR POLG 267/4885POLB 10/4885POLA1 71/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.