Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 15/20 | 0.41 |
| ▸ | ABL1 | P00519 | 13/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.40 |
| ▸ | HCK | P08631 | 11/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.40 |
| ▸ | MTOR | P42345 | 11/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.40 |
| ▸ | PRKDC | P78527 | 11/20 | 0.40 |
| ▸ | KDR | P35968 | 10/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.40 |
| ▸ | EGFR | P00533 | 10/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19414291 | 0.76 | SRC (0.40) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL149180 | 0.75 | PIK3CD (0.55) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL13717931 | 0.75 | SRC (0.48) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL16665685 | 0.73 | PIK3CD (0.67) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL19414295 | 0.72 | SRC (0.47) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL11306 | 0.72 | SRC (0.47) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL11214 | 0.70 | DYRK1A (0.48) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL10811 | 0.70 | SRC (0.57) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL17365228 | 0.69 | PDGFRB (0.46) | SRCABL1PIK3CDHCKPIK3CA | |
| SCHEMBL149528 | 0.69 | KDR (0.52) | SRCABL1PIK3CDHCKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3398950-B1 | NOVEL KINASE INHIBITOR AGAINST WILD-TYPE EGFR AND MUTATED EGFR | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-08-11 | — | — | EP | disclosed |