Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 9/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.44 |
| ▸ | PRKDC | P78527 | 7/20 | 0.44 |
| ▸ | ABL1 | P00519 | 7/20 | 0.44 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | HCK | P08631 | 6/20 | 0.44 |
| ▸ | MTOR | P42345 | 6/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149180 | 0.84 | PIK3CD (0.55) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17375380 | 0.82 | PIK3CD (0.67) | PDGFRBPDGFRASRCPIK3CDPIK3CA | |
| SCHEMBL19414295 | 0.81 | SRC (0.47) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11306 | 0.81 | SRC (0.47) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665685 | 0.79 | PIK3CD (0.67) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10811 | 0.79 | SRC (0.57) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11214 | 0.79 | DYRK1A (0.48) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28456717 | 0.77 | SRC (0.74) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1320032 | 0.76 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL149528 | 0.75 | KDR (0.52) | SRCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160968-B1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2018-10-31 | — | — | EP | claimed |
| US-9708329-B2 | Selective dual inhibitors of PI3 delta and gamma protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-07-18 | — | — | US | claimed |
| EP-3160968-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | Rhizen Pharmaceuticals S.A. (CH) | 2017-05-03 | — | — | EP | claimed |
| US-20150376188-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-12-31 | — | — | US | claimed |
| WO-2015198289-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2015-12-30 | — | — | WO | claimed |
| US-11352359-B2 | PI3K protein kinase inhibitors | RHIZEN PHARMACEUTICALS AG (CH) | 2022-06-07 | — | — | US | disclosed |
| US-20200199133-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2020-06-25 | — | — | US | disclosed |
| US-20200199133-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2020-06-25 | — | — | US | disclosed |
| CN-111153905-A | PI3K protein kinase inhibitors, in particular delta inhibitors and/or gamma inhibitors | 理森制药股份公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-105431437-B | PI3K protein kinase inhibitors, in particular delta inhibitors and/or gamma inhibitors | 理森制药股份公司 | 2020-03-10 | — | — | CN | disclosed |
| US-20190202836-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2019-07-04 | — | — | US | disclosed |
| US-20190202836-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2019-07-04 | — | — | US | disclosed |
| US-9708329-B2 | Selective dual inhibitors of PI3 delta and gamma protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-07-18 | — | — | US | disclosed |
| US-9708329-B2 | Selective dual inhibitors of PI3 delta and gamma protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-07-18 | — | — | US | disclosed |
| EP-3160968-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | Rhizen Pharmaceuticals S.A. (CH) | 2017-05-03 | — | — | EP | disclosed |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2016-07-21 | — | — | US | disclosed |
| US-20150376188-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-12-31 | — | — | US | disclosed |
| US-20150376188-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-12-31 | — | — | US | disclosed |
| WO-2015198289-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015198289-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352359-B2 | PI3K protein kinase inhibitors | PIK3CD, PIK3R5, PIK3CB | PDGFRB 548/4885PDGFRA 874/4885SRC 355/4885 |
| US-20190202836-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | PIK3CD, PRKCZ, PRKCE | PDGFRB 454/4885PDGFRA 538/4885SRC 378/4885 |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | PRKCZ, PRKCE, PRKCA | PDGFRB 496/4885PDGFRA 780/4885SRC 330/4885 |
| US-20150376188-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | PIK3CD, PRKCZ, PRKCE | PDGFRB 454/4885PDGFRA 538/4885SRC 378/4885 |
| US-20200199133-A1 | SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | PIK3CD, PRKCZ, PRKCE | PDGFRB 454/4885PDGFRA 538/4885SRC 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.