Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21610088 | 0.91 | — | — | |
| SCHEMBL20326197 | 0.88 | — | — | |
| SCHEMBL21794811 | 0.86 | ALDH1A1 (0.32) | — | |
| SCHEMBL24337264 | 0.85 | — | — | |
| SCHEMBL20326367 | 0.80 | LMNA (0.33) | LMNA | |
| SCHEMBL21741220 | 0.76 | POLB (0.37) | — | |
| SCHEMBL20334812 | 0.76 | CHRNB2 (0.31) | — | |
| SCHEMBL22880898 | 0.76 | — | — | |
| SCHEMBL20315045 | 0.75 | — | — | |
| SCHEMBL20326205 | 0.73 | MEN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |