Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10734095 | 0.77 | ATM (0.39) | ATMSMN1; SMN2POLBRAD52L3MBTL1 | |
| SCHEMBL13804182 | 0.77 | CYP2A6 (0.44) | NCF1SMN1; SMN2NUDT1HTR3AALDH1A1 | |
| SCHEMBL10732462 | 0.77 | L3MBTL1 (0.53) | NCF1ATMSMN1; SMN2POLBRAD52 | |
| SCHEMBL13804174 | 0.76 | NCF1 (0.42) | NCF1L3MBTL1NUDT1HTR3AALDH1A1 | |
| SCHEMBL21786398 | 0.76 | NCF1 (0.42) | NCF1NUDT1HTR3AALDH1A1KDM4E | |
| SCHEMBL28242430 | 0.76 | ATM (0.38) | ATMSMN1; SMN2POLBRAD52L3MBTL1 | |
| SCHEMBL20114417 | 0.76 | POLB (0.41) | ATMSMN1; SMN2POLBRAD52GABRP | |
| SCHEMBL8034196 | 0.76 | REN (0.43) | NCF1ATMSMN1; SMN2POLBRAD52 | |
| SCHEMBL16516540 | 0.76 | L3MBTL1 (0.44) | ATMSMN1; SMN2POLBRAD52L3MBTL1 | |
| SCHEMBL10477024 | 0.74 | POLB (0.43) | SMN1; SMN2POLBRAD52L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |