Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.48 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860093 | 0.82 | ROCK2 (0.61) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL19860065 | 0.82 | ROCK1 (0.61) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL24735962 | 0.82 | IMPDH2 (0.69) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL20429487 | 0.81 | ROCK2 (0.61) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL21657779 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1MYLK4 | |
| SCHEMBL18827640 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1MYLK4 | |
| SCHEMBL18827638 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1MYLK4 | |
| SCHEMBL24736559 | 0.80 | IMPDH2 (0.51) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL24736084 | 0.80 | ROCK1 (0.61) | NOTUMROCK2IMPDH2PRMT3ROCK1 | |
| SCHEMBL21679904 | 0.79 | ROCK2 (0.71) | NOTUMROCK2IMPDH2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023136942-A1 | SYNTHETIC INTERMEDIATES AND IMPROVED PROCESSES FOR PREPARING ROCK INHIBITORS | AERIE PHARMACEUTICALS, INC. (US) | 2023-07-20 | — | — | WO | disclosed |
| EP-3376870-B1 | PROCESS FOR THE PREPARATION OF KINASE INHIBITORS AND INTERMEDIATES THEREOF | AERIE PHARMACEUTICALS INC (US) | 2021-08-11 | — | — | EP | disclosed |