Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | IDH2 | P48735 | 2/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31646435 | 0.85 | P2RX7 (0.49) | P2RX7MAOBADORA2AADRB1HCRTR1 | |
| SCHEMBL26046016 | 0.83 | P2RX7 (0.49) | P2RX7MAOBADORA2AADRB1HCRTR1 | |
| SCHEMBL30864787 | 0.82 | SYK (0.47) | P2RX7MAOBMBOAT4SYKKMT2A | |
| SCHEMBL534133 | 0.82 | SYK (0.47) | P2RX7MAOBMBOAT4SYKKMT2A | |
| SCHEMBL2374158 | 0.80 | KMT2A (0.46) | P2RX7KMT2A | |
| SCHEMBL8247000 | 0.79 | ADORA2A (0.49) | P2RX7ADORA2A | |
| SCHEMBL15418113 | 0.79 | MTNR1A (0.39) | MBOAT4KMT2A | |
| SCHEMBL29755971 | 0.78 | P2RX7 (0.50) | P2RX7MAOBADORA2AADAMTS4MMP13 | |
| SCHEMBL868879 | 0.78 | P2RX7 (0.50) | P2RX7MAOBADORA2AADAMTS4MMP13 | |
| SCHEMBL22396731 | 0.77 | PSEN1 (0.42) | P2RX7ADRB1HCRTR1HCRTR2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |