Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.43 |
| ▸ | DRD3 | P35462 | 8/20 | 0.43 |
| ▸ | HTR2A | P28223 | 10/20 | 0.42 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739650 | 0.96 | DRD2 (0.40) | DRD2DRD3HTR2AHTR1AFAAH | |
| SCHEMBL23739567 | 0.89 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL23739525 | 0.88 | DRD2 (0.52) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL23739667 | 0.81 | POLB (0.35) | GAA | |
| SCHEMBL23739899 | 0.80 | POLB (0.34) | GAA | |
| SCHEMBL23739890 | 0.78 | POLB (0.35) | HTR2AGAA | |
| SCHEMBL24572202 | 0.77 | POLB (0.35) | GAA | |
| SCHEMBL23739756 | 0.77 | MAPT (0.44) | HTR1AGAA | |
| SCHEMBL23739521 | 0.77 | POLB (0.35) | HTR2AGAA | |
| SCHEMBL23934426 | 0.76 | POLB (0.34) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |