Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 8/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373407 | 0.85 | NOTUM (0.60) | NOTUMSCN9ASCN10ADRD4P2RX4 | |
| SCHEMBL5568369 | 0.81 | NOTUM (0.70) | NOTUMDRD4AKT1ARPIK3CD | |
| SCHEMBL2373630 | 0.80 | GPR119 (0.43) | NOTUMSCN9ASCN10AP2RX4PTGDR2 | |
| SCHEMBL2778816 | 0.79 | NPC1 (0.64) | NOTUMP2RX4NPC1RAB9AL3MBTL1 | |
| SCHEMBL29911845 | 0.77 | NOTUM (0.65) | NOTUMSCN9ADRD4AKT1AR | |
| SCHEMBL868581 | 0.77 | NOTUM (0.65) | NOTUMSCN9ADRD4AKT1AR | |
| SCHEMBL1127318 | 0.76 | NOTUM (1.00) | NOTUMDRD4AKT1 | |
| SCHEMBL30184535 | 0.76 | NOTUM (1.00) | NOTUMDRD4AKT1 | |
| SCHEMBL2373892 | 0.75 | NOTUM (0.45) | NOTUMSCN9ASCN10AP2RX4NPC1 | |
| SCHEMBL23042904 | 0.74 | NOTUM (0.73) | NOTUMDRD4AKT1PIK3CDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |