Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373984 | 0.85 | NOTUM (0.60) | NOTUMDRD4P2RX4ARNPC1 | |
| SCHEMBL5568858 | 0.81 | NOTUM (0.70) | NOTUMDRD2DRD4HTR2CHTR2A | |
| SCHEMBL2373892 | 0.80 | NOTUM (0.45) | NOTUMP2RX4HTR2CHTR2ANPC1 | |
| SCHEMBL2778816 | 0.79 | NPC1 (0.64) | NOTUMP2RX4NPC1RAB9AL3MBTL1 | |
| SCHEMBL868725 | 0.77 | NOTUM (0.65) | NOTUMDRD2DRD4HTR2CHTR2A | |
| SCHEMBL5765327 | 0.76 | NOTUM (1.00) | NOTUMDRD2DRD4HTR2CHTR2A | |
| SCHEMBL5766165 | 0.76 | NOTUM (1.00) | NOTUMDRD2DRD4HTR2CHTR2A | |
| SCHEMBL2373630 | 0.75 | GPR119 (0.43) | NOTUMP2RX4NPC1RAB9AL3MBTL1 | |
| SCHEMBL2375244 | 0.74 | NOTUM (0.73) | NOTUMDRD2DRD4HTR2CHTR2A | |
| SCHEMBL5565636 | 0.72 | NOTUM (0.68) | NOTUMDRD2DRD4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |