Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373630 | 0.85 | GPR119 (0.43) | NOTUMGPR119P2RX4MEN1HPGD | |
| SCHEMBL2373407 | 0.80 | NOTUM (0.60) | NOTUMP2RX4NPC1RAB9AL3MBTL1 | |
| SCHEMBL869312 | 0.79 | GPR119 (0.50) | NOTUMGPR119MEN1KMT2AHTR2A | |
| SCHEMBL2373819 | 0.75 | ABHD6 (0.59) | NOTUMGPR119NPC1RAB9AL3MBTL1 | |
| SCHEMBL2373984 | 0.75 | NOTUM (0.60) | NOTUMP2RX4NPC1RAB9AL3MBTL1 | |
| SCHEMBL2778816 | 0.71 | NPC1 (0.64) | NOTUMP2RX4MEN1KMT2ANPC1 | |
| SCHEMBL2375293 | 0.71 | EIF2AK3 (0.51) | — | |
| SCHEMBL2374492 | 0.69 | GPR119 (0.37) | NOTUMGPR119P2RX4MEN1HPGD | |
| SCHEMBL18392313 | 0.68 | PDK1 (0.50) | HPGD | |
| SCHEMBL7653263 | 0.68 | NOTUM (0.70) | NOTUMGPR119HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |