Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743731 | 0.89 | AKR1B1 (0.59) | SMN1; SMN2AKR1B1MAPK1ALDH1A1KMT2A | |
| SCHEMBL2687097 | 0.87 | EGFR (0.45) | SMN1; SMN2NLRP3ALDH1A1KMT2AKDM4E | |
| SCHEMBL31514215 | 0.85 | NLRP3 (0.54) | AKR1B1MAPK1NLRP3ALDH1A1KMT2A | |
| SCHEMBL28158406 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2AKR1B1MAPK1ALDH1A1KMT2A | |
| SCHEMBL13136744 | 0.82 | MAPK1 (0.45) | SMN1; SMN2AKR1B1P2RX7MAPK1NLRP3 | |
| SCHEMBL838467 | 0.81 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1KMT2AKDM4ETSHR | |
| SCHEMBL7593366 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2AKR1B1MAPK1ALDH1A1KMT2A | |
| SCHEMBL3044981 | 0.80 | AKR1B1 (0.74) | AKR1B1P2RX7MAPK1KMT2AKDM4E | |
| SCHEMBL7674948 | 0.80 | AKR1B1 (0.52) | SMN1; SMN2AKR1B1P2RX7MAPK1ALDH1A1 | |
| SCHEMBL8278400 | 0.80 | AKR1B1 (0.52) | SMN1; SMN2AKR1B1P2RX7MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068452-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | disclosed |
| US-8901038-B2 | Biphenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2014-12-02 | — | — | US | disclosed |
| CN-102834378-A | Biphenyl-substituted cyclic keto-enols | BAYER CROPSCIENCE AG | 2012-12-19 | — | — | CN | disclosed |
| US-20110230346-A1 | Biphenyl-Substituted Cyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-09-22 | — | — | US | disclosed |
| US-20100222326-A1 | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders | UCB PHARMA, S.A. (BE) | 2010-09-02 | — | — | US | disclosed |
| US-20100222326-A1 | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders | UCB PHARMA, S.A. (BE) | 2010-09-02 | — | — | US | disclosed |
| WO-2008132139-A2 | NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | UCB PHARMA S.A. (BE) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008132142-A2 | NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | UCB PHARMA S.A. (BE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222326-A1 | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders | CNR2, CNR1, SLC18A2 | SMN1; SMN2 144/4885AKR1B1 1913/4885P2RX7 293/4885 |
| US-20110230346-A1 | Biphenyl-Substituted Cyclic Ketoenols | KCNE1, KDM4E, PIKFYVE | SMN1; SMN2 4244/4885AKR1B1 116/4885P2RX7 785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.