Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 3/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 9/20 | 0.32 |
| ▸ | WNT1 | P04628 | 7/20 | 0.32 |
| ▸ | CLK2 | P49760 | 4/20 | 0.32 |
| ▸ | CLK3 | P49761 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623966 | 0.81 | AKT1 (0.33) | — | |
| SCHEMBL24219319 | 0.81 | GSK3B (0.39) | DYRK1AABL1GSK3BWNT1JAK2 | |
| SCHEMBL23048883 | 0.79 | NNMT (0.36) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL20938733 | 0.79 | NNMT (0.39) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL23740820 | 0.79 | GSK3B (0.52) | DYRK1AABL1GSK3BWNT1 | |
| SCHEMBL24219190 | 0.78 | DYRK1A (0.41) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24218886 | 0.78 | GSK3B (0.40) | DYRK1AABL1GSK3BWNT1CLK2 | |
| SCHEMBL23740771 | 0.78 | DYRK1A (0.36) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL23048847 | 0.78 | HCAR3 (0.33) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL24219047 | 0.77 | NNMT (0.37) | NNMTHCAR3DYRK1AACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943086-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BioSplice Therapeutics, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |