Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983987 | 0.83 | NPC1 (0.60) | ROCK1NPC1RAB9AL3MBTL1NOTUM | |
| SCHEMBL31167558 | 0.81 | USP30 (0.43) | GPR119ABHD6NOTUMAAK1PRMT5 | |
| SCHEMBL868675 | 0.81 | USP30 (0.43) | GPR119ABHD6NOTUMAAK1PRMT5 | |
| SCHEMBL12502368 | 0.81 | NOTUM (0.43) | ROCK1NOTUMCYP11B1ALDH1A1 | |
| SCHEMBL4525414 | 0.81 | NOTUM (0.56) | NPC1RAB9ANOTUMKDM4ECYP11B1 | |
| SCHEMBL23063812 | 0.80 | CYP11B1 (0.51) | ROCK1KDM4ECYP11B1ALDH1A1MAPT | |
| SCHEMBL29995958 | 0.80 | CYP11B1 (0.51) | ROCK1KDM4ECYP11B1ALDH1A1MAPT | |
| SCHEMBL12077440 | 0.78 | ADRB2 (0.47) | ROCK1NPC1RAB9ANOTUMMAPT | |
| SCHEMBL2374492 | 0.77 | GPR119 (0.37) | GPR119NOTUMMEN1KMT2A | |
| SCHEMBL28988093 | 0.77 | ROCK1 (0.38) | ROCK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |