Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911627 | 0.82 | GPR119 (0.44) | GPR119NOTUMUCHL1MEN1KMT2A | |
| SCHEMBL867519 | 0.82 | GPR119 (0.44) | GPR119NOTUMUCHL1MEN1KMT2A | |
| SCHEMBL23042880 | 0.81 | NOTUM (0.37) | GPR119NOTUM | |
| SCHEMBL2373630 | 0.78 | GPR119 (0.43) | GPR119SCN9ASCN10AP2RX4IDO1 | |
| SCHEMBL2374094 | 0.77 | GPR119 (0.42) | GPR119NOTUMMEN1KMT2A | |
| SCHEMBL2373984 | 0.73 | NOTUM (0.60) | SCN9ASCN10AP2RX4PTGDR2NOTUM | |
| SCHEMBL23042917 | 0.72 | CYP3A4 (0.53) | — | |
| SCHEMBL30120760 | 0.71 | AKT1 (0.39) | NOTUM | |
| SCHEMBL24651169 | 0.71 | AKT1 (0.39) | NOTUM | |
| SCHEMBL24344110 | 0.70 | GPR119 (0.43) | GPR119NOTUMUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015056180-A1 | INDOLINE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |