Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.51 |
| ▸ | GSK3B | P49841 | 17/20 | 0.51 |
| ▸ | WNT1 | P04628 | 5/20 | 0.51 |
| ▸ | CLK2 | P49760 | 3/20 | 0.51 |
| ▸ | CLK3 | P49761 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23741119 | 0.95 | DYRK1A (0.53) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219006 | 0.92 | DYRK1A (0.58) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740727 | 0.90 | DYRK1A (0.57) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740960 | 0.88 | DYRK1A (0.63) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23741134 | 0.84 | GSK3B (0.56) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL23740780 | 0.83 | GSK3B (0.53) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL24219244 | 0.83 | DYRK1A (0.40) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740961 | 0.82 | DYRK1A (0.51) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219230 | 0.80 | DYRK1A (0.34) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938733 | 0.80 | NNMT (0.39) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |