Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25162450 | 0.90 | MAPT (0.44) | TSHRSMN1; SMN2MAPK1ADCY1MAPT | |
| SCHEMBL23744343 | 0.88 | RAB9A (0.41) | TSHRSMN1; SMN2MAPK1MAPTTP53 | |
| SCHEMBL25162945 | 0.79 | MEN1 (0.44) | SMN1; SMN2MAPK1MAPTNPC1RAB9A | |
| SCHEMBL23744364 | 0.77 | MEN1 (0.52) | SMN1; SMN2MAPTLMNAKDM4ENPSR1 | |
| SCHEMBL23744362 | 0.77 | POLB (0.43) | MAPK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL25162946 | 0.77 | IRAK4 (0.40) | MAPK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22849214 | 0.75 | IRAK4 (0.60) | — | |
| SCHEMBL25162446 | 0.75 | MEN1 (0.47) | TSHRADCY1RAB9ALMNAKDM4E | |
| SCHEMBL23744953 | 0.72 | OPRM1 (0.39) | KMT2A | |
| SCHEMBL25162416 | 0.69 | IRAK4 (0.43) | SMN1; SMN2MAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |