Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 14/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23745421 | 0.79 | ADAMTS5 (0.66) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745290 | 0.77 | ADAMTS5 (0.45) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745414 | 0.72 | ADAMTS5 (0.55) | ADAMTS5ADAMTS4ADAM17 | |
| SCHEMBL23745422 | 0.72 | ADAMTS5 (0.55) | ADAMTS5ADAMTS4ADAM17 | |
| SCHEMBL21404021 | 0.71 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19691922 | 0.71 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23537246 | 0.70 | DRD4 (0.50) | ACEDRD1DRD4 | |
| SCHEMBL23745420 | 0.70 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19692450 | 0.69 | ADAM17 (0.68) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19692451 | 0.69 | ADAM17 (0.68) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |