Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.47 |
| ▸ | CHRNG | P07510 | 1/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRND | Q07001 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31742565 | 0.86 | CHRNB2 (0.65) | CHRNB2CHRNA4CYP3A4ORAI1CHRNA3 | |
| SCHEMBL9263607 | 0.83 | CHRNB2 (0.57) | CHRNB2CHRNA4CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL7536878 | 0.83 | CHRNB2 (0.57) | CHRNB2CHRNA4CYP19A1LMNATDP1 | |
| SCHEMBL525095 | 0.82 | CYP2D6 (0.56) | CYP3A4CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL10090161 | 0.82 | CHRNB2 (0.66) | CHRNB2CHRNA4CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL29985985 | 0.82 | CHRNB2 (0.66) | CHRNB2CHRNA4CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL19875367 | 0.80 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL238711 | 0.80 | CHRNB2 (0.62) | CHRNB2CHRNA4CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL1875084 | 0.80 | CHRNB2 (0.62) | CHRNB2CHRNA4CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL3266596 | 0.80 | CHRNB2 (0.62) | CHRNB2CHRNA4ORAI1KMT2ACHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246147-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246147-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | CHRNB2 2395/4885CHRNA4 1706/4885CYP3A4 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.