Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23746992 | 0.85 | EGFR (0.42) | PTGS1PTGS2CHRNA7HTR3ABRAF | |
| SCHEMBL23747216 | 0.84 | EDNRB (0.40) | CHRNA7HTR3AKCNH2BRAF | |
| SCHEMBL23747204 | 0.74 | AKR1B1 (0.37) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL23746985 | 0.73 | ALDH1A1 (0.49) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL23747092 | 0.72 | FFAR4 (0.44) | — | |
| SCHEMBL23747015 | 0.72 | CCR4 (0.42) | — | |
| SCHEMBL23747030 | 0.71 | FKBP1A (0.43) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL23747096 | 0.71 | EDNRA (0.42) | — | |
| SCHEMBL23747016 | 0.70 | CHRNA7 (0.41) | CHRNA7HTR3AKCNH2BRAF | |
| SCHEMBL23746986 | 0.69 | EGFR (0.44) | PTGS1CHRNA7HTR3ABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158516-A1 | IRE1α MODULATORS AND USES THEREOF | NIMBUS IASO, INC. (US) | 2021-08-12 | — | — | WO | disclosed |