Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.78 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.78 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.69 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.61 |
| ▸ | BCR | P11274 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.61 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | PLAU | P00749 | 3/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755086 | 0.96 | CYP11B2 (0.77) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL22402247 | 0.96 | CYP11B2 (0.77) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL27945362 | 0.92 | CYP11B2 (0.73) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| Methyl Alcohol SCHEMBL29235275 | 0.92 | CYP11B2 (0.73) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL5980264 | 0.92 | CYP11B2 (0.73) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL2123715 | 0.88 | HSD17B1 (0.74) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL27649742 | 0.88 | ABL1 (0.77) | CYP11B2CYP11B1ABL1ABCB1BCR | |
| SCHEMBL25041887 | 0.86 | CYP1A2 (0.83) | CYP11B2CYP11B1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL3020390 | 0.86 | HSD17B1 (0.76) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 | |
| SCHEMBL12051687 | 0.85 | HSD17B1 (0.83) | CYP11B2CYP11B1HSD17B1HSD17B2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11547701-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210244717-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11547701-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | CYP11B2 427/4885CYP11B1 455/4885HSD17B1 2404/4885 |
| US-20210244717-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | CYP11B2 611/4885CYP11B1 703/4885HSD17B1 3466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.