Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747488 | 0.89 | TSHR (0.72) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL23747357 | 0.85 | SMN1; SMN2 (0.63) | ALDH1A1HPGDSMN1; SMN2ALOX15NPC1 | |
| SCHEMBL23747484 | 0.83 | SMN1; SMN2 (0.60) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL26547359 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1KDM4ESMN1; SMN2REV1NPC1 | |
| SCHEMBL26550313 | 0.81 | SMN1; SMN2 (0.58) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL17916794 | 0.81 | SMN1; SMN2 (0.88) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL23747424 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ATSHRHIF1A | |
| SCHEMBL9836017 | 0.78 | SMN1; SMN2 (1.00) | HPGDSMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL23747552 | 0.78 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23747448 | 0.77 | CHRM1 (0.69) | ALDH1A1KDM4ESMN1; SMN2ALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | ALDH1A1 2019/4885KDM4E 2721/4885HPGD 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.