Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GALR3 | O60755 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.57 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747360 | 0.89 | ALDH1A1 (0.73) | TSHRHIF1AEPAS1MAPTSMN1; SMN2 | |
| SCHEMBL23747448 | 0.88 | CHRM1 (0.69) | KMT2AMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23747424 | 0.88 | SMN1; SMN2 (0.59) | TSHRHIF1AEPAS1KMT2AMAPT | |
| SCHEMBL26547285 | 0.88 | SMN1; SMN2 (0.61) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 | |
| SCHEMBL26558192 | 0.87 | SMN1; SMN2 (0.64) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 | |
| SCHEMBL26101263 | 0.85 | SMN1; SMN2 (0.61) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 | |
| SCHEMBL26101062 | 0.85 | SMN1; SMN2 (0.61) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 | |
| SCHEMBL23747569 | 0.85 | PKM (0.72) | TSHRHIF1AEPAS1KMT2AMAPT | |
| SCHEMBL23747572 | 0.85 | SMN1; SMN2 (0.61) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 | |
| SCHEMBL26547393 | 0.85 | SMN1; SMN2 (0.61) | TSHRHIF1AEPAS1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | TSHR 562/4885HIF1A 2748/4885EPAS1 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.