Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676531 | 0.88 | NPC1 (0.50) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL2676537 | 0.86 | NPC1 (0.46) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL23747623 | 0.86 | NPC1 (0.49) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL27483144 | 0.83 | MAPT (0.48) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL11026695 | 0.81 | MAPT (0.43) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL11027473 | 0.81 | MAPT (0.50) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL378398 | 0.80 | ALDH1A1 (0.47) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL6308371 | 0.79 | ALDH1A1 (0.46) | MAPTKDM4ELMNABCL9CTNNB1 | |
| SCHEMBL19520108 | 0.77 | LMNA (0.44) | KDM4ELMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL4315175 | 0.77 | LMNA (0.44) | KDM4ELMNAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |