Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308371 | 0.87 | ALDH1A1 (0.46) | ALDH1A1MAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL6704873 | 0.83 | ALDH1A1 (0.42) | ALDH1A1MAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL2676531 | 0.83 | NPC1 (0.50) | ALDH1A1MAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL23747623 | 0.82 | NPC1 (0.49) | ALDH1A1MAPTMAPK1KDM4ENPC1 | |
| SCHEMBL2676537 | 0.82 | NPC1 (0.46) | ALDH1A1MAPTMAPK1TDP1KDM4E | |
| SCHEMBL28462836 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL8727031 | 0.80 | MGLL (0.46) | ALDH1A1MAPTL3MBTL1CYP19A1BCL9 | |
| SCHEMBL11308398 | 0.80 | MGLL (0.46) | ALDH1A1MAPTL3MBTL1CYP19A1BCL9 | |
| SCHEMBL23747427 | 0.80 | MAPT (0.47) | ALDH1A1MAPTMAPK1KDM4ENPC1 | |
| SCHEMBL9165350 | 0.80 | MGLL (0.46) | ALDH1A1MAPTL3MBTL1CYP19A1BCL9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408741-A1 | METHOD FOR COUPLING HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS WITH ORGANIC COMPOUNDS COMPRISING TRIALKYLSILYL-SUBSTITUTED HETEROATOMS | Zylum Beteiligungsgesellschaft mbH & Co. Patente II KG (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106078-A1 | METHOD FOR COUPLING HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS WITH ORGANIC COMPOUNDS COMPRISING TRIALKYLSILYL-SUBSTITUTED HETEROATOMS | ZYLUM BETEILIGUNGSGESELLSCHAFT MBH & CO. PATENTE II KG (DE) | 2010-09-23 | — | — | WO | disclosed |