Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23748175 | 0.85 | DRD2 (0.36) | KAT6AALDH1A1CYP2D6SLC6A4SLC22A1 | |
| SCHEMBL24353419 | 0.84 | HTR2C (0.36) | HTR2CHTR2BKAT6AALDH1A1CYP2D6 | |
| SCHEMBL23856042 | 0.82 | HTR2C (0.32) | HTR2CHTR2BTLR4 | |
| SCHEMBL23856050 | 0.80 | MAPT (0.34) | HTR2CHTR2BALDH1A1TLR4TSHR | |
| SCHEMBL23748225 | 0.78 | ADRB2 (0.39) | HTR2CHTR2BKAT6AALDH1A1CYP2D6 | |
| SCHEMBL23856039 | 0.77 | HTR2C (0.34) | HTR2CHTR2BALDH1A1CYP2D6TLR4 | |
| SCHEMBL30219209 | 0.77 | HTR2C (0.34) | HTR2CHTR2BALDH1A1CYP2D6TLR4 | |
| SCHEMBL23748280 | 0.77 | CXCR5 (0.46) | ALDH1A1CYP2D6SLC6A4SLC22A1LMNA | |
| SCHEMBL23856040 | 0.76 | HTR2C (0.31) | HTR2CHTR2B | |
| SCHEMBL30219222 | 0.76 | HTR2C (0.33) | HTR2CHTR2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212187-A1 | FUSED RING DERIVATIVES AND USE THEREOF IN PHARMACY | CISEN PHARMACEUTICAL CO., LTD (CN) | 2023-07-06 | — | — | US | disclosed |
| US-20230002409-A1 | MACROCYCLIC FLU ENDONUCLEASE INHIBITORS | JANSSEN BIOPHARMA INC (US) | 2023-01-05 | — | — | US | disclosed |
| US-20230002409-A1 | MACROCYCLIC FLU ENDONUCLEASE INHIBITORS | JANSSEN BIOPHARMA INC (US) | 2023-01-05 | — | — | US | disclosed |
| US-11312727-B1 | Macrocyclic flu endonuclease inhibitors | Janssen Biopharma, Inc. (US) | 2022-04-26 | — | — | US | disclosed |
| US-11312727-B1 | Macrocyclic flu endonuclease inhibitors | Janssen Biopharma, Inc. (US) | 2022-04-26 | — | — | US | disclosed |
| EP-3864020-A1 | MACROCYCLIC FLU ENDONUCLEASE INHIBITORS | Janssen BioPharma, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002409-A1 | MACROCYCLIC FLU ENDONUCLEASE INHIBITORS | ACE, PNP, FEN1 | HTR2C 2220/4885HTR2B 3558/4885KAT6A 3841/4885 |
| US-11312727-B1 | Macrocyclic flu endonuclease inhibitors | ACE, FEN1, PNP | HTR2C 2792/4885HTR2B 3691/4885KAT6A 3762/4885 |
| US-20230212187-A1 | FUSED RING DERIVATIVES AND USE THEREOF IN PHARMACY | ABCB1, CYP3A43, CYP3A7 | HTR2C 1561/4885HTR2B 931/4885KAT6A 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.