Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 2/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | HNF4A | P41235 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39623 | 0.98 | HMGB1 (0.65) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| SCHEMBL29695710 | 0.98 | HMGB1 (0.65) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL11527302 | 0.96 | HMGB1 (0.62) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| SCHEMBL27360496 | 0.96 | HMGB1 (0.62) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| Bicarbonate SCHEMBL236594 | 0.87 | HMGB1 (0.67) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| Bicarbonate SCHEMBL22573123 | 0.87 | HMGB1 (0.67) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| SCHEMBL18928220 | 0.85 | KMT2A (0.65) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| SCHEMBL9859 | 0.85 | HMGB1 (0.69) | HMGB1GABRA1GABRB2ALDH1A1KDM4E | |
| Bicarbonate SCHEMBL22573105 | 0.84 | HMGB1 (0.63) | HMGB1ALDH1A1KDM4EHPGDHSD17B10 | |
| Bicarbonate SCHEMBL237561 | 0.84 | HMGB1 (0.63) | HMGB1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371609-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO LLC | 2021-12-02 | — | — | US | disclosed |
| EP-3707198-B1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO DEUTSCHLAND AG (DE) | 2021-10-27 | — | — | EP | disclosed |
| EP-3707198-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | Covestro Deutschland AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10131178-B2 | Layered structure and films for ID documents having improved properties for laser engraving | COVESTRO DEUTSCHLAND AG (DE) | 2018-11-20 | — | — | US | disclosed |
| EP-2820071-B1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | COVESTRO DEUTSCHLAND AG (DE) | 2017-03-22 | — | — | EP | disclosed |
| US-9108357-B2 | Multilayer decorative film | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| EP-2820071-A1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | Bayer Intellectual Property GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2694698-A1 | A PROCESS FOR MULTI-LAYER CONTINUOUS ROLL-TO-ROLL COATING | Bayer Intellectual Property GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| EP-2640581-A1 | MULTILAYER DECORATIVE FILM | Bayer Intellectual Property GmbH (DE) | 2013-09-25 | — | — | EP | disclosed |
| US-20130236719-A1 | MULTILAYER DECORATIVE FILM | COVESTRO DEUTSCHLAND AG (DE) | 2013-09-12 | — | — | US | disclosed |
| EP-2634208-A1 | Process for the production of low stress and optical quality film for use in opto-electronic devices | Bayer MaterialScience AG (DE) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012136529-A1 | A PROCESS FOR MULTI-LAYER CONTINUOUS ROLL-TO-ROLL COATING | BAYER MATERIALSCIENCE AG (DE) | 2012-10-11 | — | — | WO | disclosed |
| EP-2508646-A1 | A process for multi-layer continuous roll-to-roll coating | Bayer Material Science AG (DE) | 2012-10-10 | — | — | EP | disclosed |
| WO-2012065966-A1 | MULTILAYER DECORATIVE FILM | BAYER MATERIALSCIENCE AG (DE) | 2012-05-24 | — | — | WO | disclosed |
| US-8168110-B2 | Method for producing a deep-drawn film part from a thermoplastic material | BAYER MATERIALSCIENCE AG (DE) | 2012-05-01 | — | — | US | disclosed |
| US-20120001413-A1 | LAYER STRUCTURE AND FILMS FOR ID DOCUMENTS HAVING IMPROVED PROPERTIES FOR LASER ENGRAVING | BAYER MATERIALSCIENCE AG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110193337-A1 | FORGERY-PROOF SECURITY FEATURES IN SECURITY OR VALUE DOCUMENTS | BAYER MATERIAL SCIENCE AG (DE) | 2011-08-11 | — | — | US | disclosed |
| US-20100237544-A1 | METHOD FOR PRODUCING A DEEP-DRAWN FILM PART FROM A THERMOPLASTIC MATERIAL | BAYER MATERIALSCIENCE AG (DE) | 2010-09-23 | — | — | US | disclosed |
| US-7091302-B2 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20050239995-A1 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG | 2005-10-27 | — | — | US | disclosed |