SCHEMBL18928220

SCHEMBL18928220

CCc1cccc(C(=O)c2ccccc2C(=O)O)c1O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.65
CYP3A4 P08684 1/20 0.65
CYP2C9 P11712 1/20 0.65
GABRA1 P14867 1/20 0.53
GABRB2 P47870 1/20 0.53
HMGB1 P09429 1/20 0.51
CLCN2 P51788 1/20 0.51
ALDH1A1 P00352 4/20 0.50
CDC25B P30305 4/20 0.50
MEN1 O00255 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
AKR1C3 P42330 2/20 0.48
ALOX15 P16050 1/20 0.48
POLB P06746 2/20 0.46
PRNP P04156 1/20 0.46
KDM4E B2RXH2 2/20 0.46
HSD17B10 Q99714 2/20 0.46
HPGD P15428 1/20 0.46
GAA P10253 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16949829 0.89 GABRA1 (0.67) KMT2ACYP3A4CYP2C9GABRA1GABRB2
SCHEMBL39623 0.87 HMGB1 (0.65) KMT2ACYP3A4CYP2C9GABRA1GABRB2
SCHEMBL29695710 0.87 HMGB1 (0.65) KMT2ACYP3A4CYP2C9GABRA1GABRB2
Bicarbonate SCHEMBL237485 0.85 HMGB1 (0.62) KMT2ACYP3A4CYP2C9GABRA1GABRB2
Hydrochloric Acid SCHEMBL11527302 0.85 HMGB1 (0.62) KMT2ACYP3A4CYP2C9GABRA1GABRB2
SCHEMBL3953764 0.85 ALDH1A1 (0.56) KMT2ACYP3A4CYP2C9CLCN2ALDH1A1
SCHEMBL27360496 0.85 HMGB1 (0.62) KMT2ACYP3A4CYP2C9GABRA1GABRB2
SCHEMBL11525711 0.84 GABRA1 (0.55) KMT2ACYP3A4CYP2C9GABRA1GABRB2
SCHEMBL28351438 0.84 ALDH1A1 (0.54) KMT2ACYP3A4CYP2C9CLCN2ALDH1A1
Phthalic Acid SCHEMBL3256652 0.80 CLCN2 (0.56) KMT2ACYP3A4CYP2C9GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017093835-A1 WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF NOVARTIS AG (CH) 2017-06-08 WO disclosed