Orziloben

Orziloben

SCHEMBL23748623

CCCCCOc1cccc(C(=O)O)c1C.[CaH2]

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.56
NR1I2 O75469 1/20 0.56
LMNA P02545 1/20 0.56
CHRM2 P08172 1/20 0.56
CYP3A4 P08684 1/20 0.56
ADRA2A P08913 1/20 0.56
MAPT P10636 1/20 0.56
OPRK1 P41145 1/20 0.56
HTR2B P41595 1/20 0.56
SLC6A3 Q01959 1/20 0.56
KMT2A Q03164 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
PTPN11 Q06124 5/20 0.53
NPSR1 Q6W5P4 1/20 0.51
PTPN1 P18031 2/20 0.50
S1PR3 Q99500 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orziloben SCHEMBL6531935 0.98 MEN1 (0.57) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL23748668 0.97 MEN1 (0.60) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL20503229 0.97 MEN1 (0.60) MEN1NR1I2LMNACHRM2CYP3A4
Orziloben SCHEMBL23748710 0.97 MEN1 (0.56) MEN1NR1I2LMNACHRM2CYP3A4
Orziloben SCHEMBL28616001 0.97 MEN1 (0.56) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL4101951 0.94 KMT2A (0.51) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL25289272 0.91 ALDH1A1 (0.53) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL2340348 0.89 KMT2A (0.51) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL24087405 0.85 CYP3A4 (0.56) MEN1NR1I2LMNACHRM2CYP3A4
SCHEMBL23748604 0.85 CNR2 (0.48) MEN1NR1I2LMNACHRM2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12473249-B2 Aromatic compounds and pharmaceutical uses thereof BASF AS (NO) 2025-11-18 US claimed
US-20210380521-A1 AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF BASF AS (NO) 2021-12-09 US claimed
EP-3864001-A1 ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF BASF AS (NO) 2021-08-18 EP claimed
CN-113166024-A Aromatic compounds and their medical use 巴斯夫股份公司 2021-07-23 CN claimed
US-12473249-B2 Aromatic compounds and pharmaceutical uses thereof BASF AS (NO) 2025-11-18 US disclosed
US-20210380521-A1 AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF BASF AS (NO) 2021-12-09 US disclosed
EP-3864001-A1 ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF BASF AS (NO) 2021-08-18 EP disclosed
CN-113166024-A Aromatic compounds and their medical use 巴斯夫股份公司 2021-07-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12473249-B2 Aromatic compounds and pharmaceutical uses thereof GLS2, FFAR3, SLC10A1 MEN1 2226/4885NR1I2 282/4885LMNA 1885/4885
US-20210380521-A1 AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF GLS2, FFAR3, SLC10A1 MEN1 2226/4885NR1I2 282/4885LMNA 1885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.