Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25411556 | 0.84 | CCR1 (0.37) | ALDH1A1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL21826368 | 0.79 | HTT (0.52) | ALDH1A1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL1669519 | 0.78 | GRIN2B (0.44) | ALDH1A1MEN1LMNAKMT2AGRIN2B | |
| SCHEMBL15156029 | 0.78 | L3MBTL1 (0.41) | ALDH1A1SMN1; SMN2LMNAKMT2AGRIN2B | |
| SCHEMBL15156081 | 0.77 | OPRM1 (0.43) | MEN1LMNAKMT2ACYP2D6KDM4E | |
| SCHEMBL23112288 | 0.77 | GRIN2B (0.46) | ALDH1A1SMN1; SMN2GRIN2BCCR1OPRM1 | |
| SCHEMBL17080571 | 0.77 | TPMT (0.38) | MEN1KMT2AGRIN2BCCR1OPRM1 | |
| SCHEMBL16874757 | 0.77 | OPRM1 (0.48) | ALDH1A1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL23748773 | 0.75 | OPRM1 (0.37) | ALDH1A1GRIN2BCYP2D6OPRM1OPRD1 | |
| SCHEMBL12940192 | 0.74 | OPRM1 (0.44) | GRIN2BCYP2D6OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3863711-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | Pliant Therapeutics, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |