Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23750229 | 0.90 | F10 (0.39) | EPHX1ALOX5MTNR1AMTNR1BF10 | |
| SCHEMBL23750228 | 0.85 | GABBR2 (0.43) | GABBR2GABBR1EPHX1NOS3NOS1 | |
| SCHEMBL23750143 | 0.85 | GABBR2 (0.43) | GABBR2GABBR1EPHX1NOS3NOS1 | |
| SCHEMBL24879051 | 0.83 | GABBR2 (0.46) | GABBR2GABBR1GAALMNACYP2C9 | |
| SCHEMBL26923481 | 0.81 | NOS3 (0.42) | NOS3NOS1NOS2HTR2ATAAR1 | |
| SCHEMBL26923483 | 0.81 | NOS3 (0.42) | NOS3NOS1NOS2HTR2ATAAR1 | |
| SCHEMBL26923826 | 0.81 | NOS3 (0.42) | NOS3NOS1NOS2HTR2ATAAR1 | |
| SCHEMBL23750263 | 0.79 | GABBR2 (0.45) | GABBR2GABBR1LMNACYP2C9NFKB1 | |
| SCHEMBL24879170 | 0.79 | GABBR2 (0.45) | GABBR2GABBR1LMNACYP2C9NFKB1 | |
| SCHEMBL24879115 | 0.78 | GABBR2 (0.51) | GABBR2GABBR1GAAPTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012121-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| US-20210246169-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230012121-A1 | COMPOUNDS | MRPS18A, MRPL37, MRPL21 | GABBR2 4122/4885GABBR1 4101/4885EPHX1 3600/4885 |
| US-20210246169-A1 | COMPOUNDS | MRPS18A, MRPL37, MRPS35 | GABBR2 4179/4885GABBR1 4092/4885EPHX1 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.