Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26923481 | 1.00 | NOS3 (0.42) | NOS3NOS1NOS2PNMTTAAR1 | |
| SCHEMBL26923483 | 1.00 | NOS3 (0.42) | NOS3NOS1NOS2PNMTTAAR1 | |
| SCHEMBL23750142 | 0.81 | GABBR2 (0.42) | NOS3NOS1NOS2TAAR1HTR2A | |
| SCHEMBL23750143 | 0.79 | GABBR2 (0.43) | NOS3NOS1NOS2HTR2AGABRA1 | |
| SCHEMBL23750228 | 0.79 | GABBR2 (0.43) | NOS3NOS1NOS2HTR2AGABRA1 | |
| SCHEMBL26922835 | 0.79 | TAAR1 (0.41) | NOS3NOS1NOS2TAAR1SLC6A2 | |
| SCHEMBL26922372 | 0.79 | TAAR1 (0.41) | NOS3NOS1NOS2TAAR1SLC6A2 | |
| SCHEMBL26922368 | 0.79 | TAAR1 (0.41) | NOS3NOS1NOS2TAAR1SLC6A2 | |
| SCHEMBL13508600 | 0.77 | PNMT (0.45) | NOS3NOS1NOS2PNMT | |
| SCHEMBL11076430 | 0.77 | NOS3 (0.43) | NOS3NOS1NOS2TAAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4316504-A2 | COMPOUNDS | Spero Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3810633-B1 | COMPOUNDS | SPERO THERAPEUTICS INC (US) | 2023-12-13 | — | — | EP | disclosed |