Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 20/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.51 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373988 | 0.90 | EIF2AK3 (0.64) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL869803 | 0.85 | EIF2AK3 (0.51) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL869311 | 0.77 | EIF2AK3 (0.84) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL868916 | 0.75 | EIF2AK3 (0.64) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL869008 | 0.75 | EIF2AK3 (0.86) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL24651198 | 0.74 | SRC (0.53) | — | |
| SCHEMBL23042872 | 0.74 | EIF2AK3 (0.70) | EIF2AK3EIF2AK2EIF2AK1CYP3A4RIPK1 | |
| SCHEMBL2373892 | 0.71 | NOTUM (0.45) | — | |
| SCHEMBL24651150 | 0.71 | ABL1 (0.51) | — | |
| SCHEMBL2373645 | 0.70 | RIPK1 (0.68) | EIF2AK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |