Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753803 | 0.87 | ALK (0.46) | PDE9AALKMETLRRK2RIPK1 | |
| SCHEMBL23761240 | 0.84 | PDE9A (0.49) | PDE9AALKMETLRRK2RIPK1 | |
| SCHEMBL23761270 | 0.82 | MET (0.53) | PDE9AALKMETRIPK1 | |
| SCHEMBL21741531 | 0.82 | FGFR3 (0.48) | ALKBRD4LRRK2MAP4K4 | |
| SCHEMBL17794960 | 0.80 | BRD4 (0.43) | BRD4LRRK2ALOX5APFEN1CHRM1 | |
| SCHEMBL31677710 | 0.78 | LRRK2 (0.50) | ALKMETBRD4LRRK2ALOX5AP | |
| SCHEMBL31048702 | 0.78 | BRD4 (0.54) | PDE9ABRD4ALOX5APFEN1CHRM1 | |
| SCHEMBL18124158 | 0.78 | TGFBR1 (0.48) | ALKMETBRD4LRRK2NTRK1 | |
| SCHEMBL17794961 | 0.77 | CHRM1 (0.44) | ALOX5APFEN1CHRM1CHRM5 | |
| SCHEMBL23753783 | 0.77 | PDK2 (0.48) | METBRD4LRRK2RIPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160109-A1 | DIHYDRONAPHTHYRIDINONE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 劲方医药科技(上海)有限公司 | 2021-08-19 | — | — | WO | disclosed |