Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754756 | 0.91 | TYK2 (0.68) | TYK2STAT3PDE4D | |
| SCHEMBL21887788 | 0.84 | TYK2 (0.53) | TYK2STAT3KDM4ENPC1ALDH1A1 | |
| SCHEMBL23759204 | 0.83 | TYK2 (0.63) | TYK2STAT3PDE4D | |
| SCHEMBL22343331 | 0.80 | TYK2 (0.66) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL21811191 | 0.80 | TYK2 (0.61) | TYK2STAT3KDM4ENPC1ALDH1A1 | |
| SCHEMBL30349558 | 0.80 | TYK2 (0.61) | TYK2STAT3KDM4ENPC1ALDH1A1 | |
| SCHEMBL23754805 | 0.80 | TYK2 (1.00) | TYK2STAT3PDE4D | |
| SCHEMBL26448073 | 0.77 | TYK2 (0.87) | TYK2STAT3PDE4D | |
| SCHEMBL21948230 | 0.77 | KDM4E (0.53) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL22092687 | 0.76 | TYK2 (0.64) | TYK2STAT3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516063-B2 | Substituted 7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives for treating autoimmune diseases | ELI LILLY AND COMPANY (US) | 2026-01-06 | — | — | US | disclosed |
| EP-4103279-B1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-115052660-B | Substituted 7- (methylamino) pyrazolo [1,5-a ] pyrimidine-3-carboxamide derivatives | 伊莱利利公司 | 2024-01-09 | — | — | CN | disclosed |
| US-20230136885-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY | 2023-05-04 | — | — | US | disclosed |
| US-20230136885-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY | 2023-05-04 | — | — | US | disclosed |
| US-20230136885-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY | 2023-05-04 | — | — | US | disclosed |
| EP-4103279-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | Eli Lilly and Company (US) | 2022-12-21 | — | — | EP | disclosed |
| CN-115052660-A | Substituted 7- (methylamino) pyrazolo [1,5-a ] pyrimidine-3-carboxamide derivatives | 伊莱利利公司 | 2022-09-13 | — | — | CN | disclosed |
| WO-2021162944-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021162944-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2021-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136885-A1 | SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | SSB, IL1R1, SLC5A1 | TYK2 270/4885STAT3 100/4885KDM4E 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.